Sydenham is a suburb 25 km north-west of Melbourne, Victoria, Australia. Its local government area is the City of Brimbank. At the 2011 Census, Sydenham had a population of 10,323.
The Post Office opened on 26 August 1861.A railway station, known as Keilor Road, was opened in 1859 and renamed Sydenham on 1 April 1887. The station was relocated before reopening as Watergardens in 2002, with the extension of the electric rail service to the suburb. Watergardens is on the Sunbury railway line and was a terminus station until November 2012.